State Key Laboratory of Shield Machine and Boring Technology
Features:
1. Significantly improved competence and extended lifecycle of products
2. Multi-unit drug delivery with lower initial burst release effects
3. Steady drug release and minimal individual absorption difference.
Advantages:
1. Equipped with comprehensive machinery for sustained controlled release preparations: wet granulating machine, dry granulating machine, extruder and roller, fluidized bed, double-layer/packet chip pressing machine, and laser punching machine;
2. Successful application of skeleton sustained release technology: sustained-release tablets of leveiracetam, thiopine fumarate, hydrocortisone and potassium chloride;
3. Successful application of osmotic pump controlled release technology: controlled release tablet of nifedipine;
4. Successful application of pellet coating technology: sustained-release capsules of memantine hydrochloride and sustained-release orally disintegrating tablets of huperzine.
Features:
1. Significant improvement in solubility, dissolution rate and bioavailability of drugs
2. Marked improvement in stability, taste masking and irritation reduction.
3. Designing Around Patents.
1. Equipped with key machinery including the spray dryer and hot melt extruder;
2. Finding the best technical route (to meet the requirements posed by physical and chemical properties of drugs, clinical needs and registration regulations);
3. Successful mastery and application of various solubilization techniques: lutein soluble powder; amorphous solid dispersions such as itraconazole, fenofibrate, and flufenidone; itraconazole cyclodextrin oral solution; carbamazepine eutectic.
1. Responsive phase transition of physiological environment (pH, temperature, ion): liquid in vitro, transform into gel immediately after drug administration;
2. Prolong drug action time, improve bioavailability and reduce number of administrations;
3. Easy to control dosage.
1. Full use of polymer materials to influence phase transition related factors;
2. Systematically screening influencing factors platform;
3. Extended application to the delivery system of vaginal spray temperature-sensitive gel;
4. Equipped with rheometer and other relevant testing equipment.
1. Novel transdermal drug delivery method with high biocompatibility and goodbiodegradability;
2. Use to deliver bio-macromolecules and high-activity small-molecule drugs, significantly improving the efficiency of transdermal drug delivery;
3. Safe, long-acting, little irritation and optimal patient compliance.
1. In-depth research on material optimization, preparation methods and quality evaluation;
2. Independent intellectual property rights for the microneedle technology, testing instruments and production equipment;
3. Development of various soluble microneedle chip products.
1. Non-injection and non-invasive administration; improved patient compliance;
2. Low enzyme metabolic activity to avoid the first-pass effect of the liver;
3. Used for protein polypeptide drug delivery to improve stability
1. Extensive research on substitution of HFA for CFC;
2. Formulation of a scientific evaluation system (for formulation, technical processes, lung sedimentation rates, evacuation rates, stability, etc.)
3. Equipped with quality evaluation machinery, including aerosol filling machines, next generation pharmaceutical impactors (NGI), and Malvern particle size analyzers.
1. Strong biocompatibility and degradability; suitable for multiple administration routes;
2. Enable encapsulation of different drug substances to mask taste and improve stability;
3. Highly targeted and ensuring long-acting sustained release.
1. Adequate research on various preparation methods;
2. Independent intellectual property rights for development of the 'ultra-fine particle preparation system';
3. Successful application to development of long-acting microspheres projects such as risperidone for injection, exenatide, huperzine nail, and metoprolol.
4. Recognized translation of industrial, education and research outcomes.
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